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ead is a toxic pollutant. Radioligand binding studies of native NMDA receptors with a range of NR2B selective antagonists provided pharmacological evidence for heterogeneity in NR2B containing receptor populations in the two age groups indicating a developmental switch in early adulthood. Ligand autoradiography of human control and disease state brain sections revealed an overall preservation of NR2B receptors in the 60 92 year age range. Control female cases showed a significantly lower level of NR2B containing receptors compared to age matched control male cases